Fig. 5.

Schematic representation of muscle strength (grip test of forelimb) of P0^+/+ and P0^−/− mice (3 months of age) with and without theWld^s mutation. TheWld^s mutation has no influence on muscle strength in P0^+/+ genotypes. Muscle strength is strongly reduced in P0^−/−/WT mice, but reduction is less pronounced in P0^−/−/Wld^s-homozygous mutants. Muscle strength of P0^−/− mice carrying a heterozygous Wld^s mutation show a small, nonsignificant trend toward higher values compared with P0^−/− single mutants. ***p < 0.0005; *p <0.05. n, Number of individuals of the respective genotype investigated. WT, Wild type; hom, homozygous; het, heterozygous.