Fig. 3.

Morphological evidence for promotion of actin disassembly by latrunculin (Lat A) and stabilization of F-actin by jasplakinolide (Jas). a, DIC micrographs of live cells without jasplakinolide pretreatment show lysis and loss of cell shape (flattening) after 15 min of incubation in 1 μm latrunculin A. The dose-dependent nature of jasplakinolide stabilization of cell morphology seen inb is plotted in c. A concentration as low as 8 nm has a stabilizing effect. All cells in >20 fields were included in data plotted for each jasplakinolide concentration.