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. 2003 Jan 1;23(1):43–51. doi: 10.1523/JNEUROSCI.23-01-00043.2003

Fig. 5.

Fig. 5.

SNP- and DETA-NO-induced inhibition of ouabain-sensitive Na,K-ATPase was abolished in transgenic mutant SOD1 mice and transgenic normal human SOD1 overexpressors. Spinal cord tissue slices were incubated with or without ODQ (1 μm) for 3 min at 34°C, followed by incubation with DETA-NO (100 μm) or SNP (100 μm) for 15 min at 34°C. Drugs were removed, tissue slices were homogenized, and ouabain-sensitive Na,K-ATPase activity was measured. For all graphs that are shown, activity is expressed as μmol Pi/hr per milligram of protein, and values represent the means ± SEM for experiments on three animals done in triplicate. A, Ouabain-sensitive Na,K-ATPase activity in nontransgenic controls. *Significantly different from the control atp < 0.05 (by ANOVA and Fisher's PLSD).##Significantly different from DETA-NO- and SNP-treated samples at p < 0.05 (by ANOVA and Fisher's PLSD).B, C, Ouabain-sensitive Na,K-ATPase activity in transgenic mutant SOD1 and transgenic SOD1 normal human SOD1 overexpressors.