Fig. 5.

The effect of ketamine on PPI. The psychomimetic drug ketamine was administered 5 min before testing the acoustic startle response. As expected, ketamine diminished the PPI response (with an 80 dB prepulse) in the BALB/c mice born to sham-infected mothers (Control) (n = 14; 8 females), but it increased PPI in mice born to virus-infected mothers (Exposed) (n = 29; 15 females). The difference in the drug-induced increases between control groups and experimental groups is significant (p < 0.02). Similar results were observed for C57BL/6 mice (n = 10 and 48 for control groups and experimental groups, respectively; p < 0.04).