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The effect of maternal immune response in the absence of virus. Pregnant BALB/c mice were injected intraperitoneally on day 9.5 of pregnancy with one of three doses of poly(I:C) to evoke an antiviral-like immune response. The offspring were tested for PPI at 4 dB prepulse levels at 6–8 weeks of age. At the highest dose of poly(I:C), the offspring displayed a significant deficit in PPI (*p < 0.05; **p < 0.01) (n = 10 for each group; 5 females each).
