Table 1.

Brain Aβ40 and Aβ42 in formic acid extracts from drug-treated and vehicle-treated young PS/APP mice

	n	Aβ40       Aβ42
		Picomoles of Aβ per gram of tissue
Gelsolin-treated mice
Set 11-a
Vehicle	7	199  ± 29	226  ± 46
Gelsolin	6	89  ± 22	95  ± 30
		(p  = 0.02)	(p  = 0.049)
Set 21-b
Vehicle	9	429  ± 43	644  ± 80
Gelsolin	7	190  ± 33	314  ± 60
		(p  = 0.01)	(p  = 0.008)
GM1-treated mice
Set 11-a
Vehicle	7	199  ± 29	226  ± 46
GM1	6	112  ± 23	104  ± 28
		(p  = 0.03)	(p  = 0.04)

Data are presented as mean ± SEM.

^F1-aAβ was extracted by the four-step method (Kawarabayashi et al., 2001).

^F1-bAβ was extracted by the two-step formic acid extraction method (Janus et al., 2000).