Table 1.

Acute effects of fluoxetine on brain indoleamine levels in trkB.T1 transgenic mice

	Wild type		Transgenic
	Saline	Fluoxetine	Saline	Fluoxetine
5-HT (nmol/gm tissue)
Frontal cortex	2.31  ± 0.12	2.86  ± 0.17*	2.05  ± 0.21	2.67  ± 0.11*
Cingulate cortex	1.57  ± 0.07	1.88  ± 0.23*	1.54  ± 0.22	1.88  ± 0.21*
5-HIAA (nmol/gm)
Frontal cortex	1.52  ± 0.11	1.30  ± 0.04	1.20  ± 0.051-159	1.33  ± 0.08
Cingulate cortex	0.77  ± 0.05	0.72  ± 0.04	0.70  ± 0.05	0.70  ± 0.04

HPLC analysis of the total tissue contents of 5-HT and 5-HIAA levels in frontal and cingulate cortex from adult wild-type littermates and trkB.T1 transgenic mice 3 hr after fluoxetine (20 mg/kg) or saline intraperitoneal injection. Data are shown as means ± SEM from five to six animals per group.

^*p < 0.05, indicating the significant difference of the treatment within the same genotype;

F1-159: p < 0.05, significantly different from wild type (Student's t test).