Fig. 2.

Behavioral analyses. A, Hanging wire test. WT (n = 8) and SRC-1^−/−(n = 11) mice were placed on bars and turned upside down. The latency to fall was measured. B, Rotarod test. WT (n = 20) and SRC-1^−/−(n = 20) mice were trained three times per day for a period of 3 d. Latency to fall from the accelerating rotarod was measured. C, Morris water task. WT (n = 10) and SRC-1^−/−(n = 9) mice were trained with four trials per day for 7 d. Mean escape latency was measured in the hidden platform version of the Morris water task. D, Swim speed. WT (n = 9) and SRC-1^−/−(n = 9) mice were allowed to swim in the pool for 60 sec. Mean swim speed was measured from four consecutive trials.