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. 2003 May 1;23(9):3916–3923. doi: 10.1523/JNEUROSCI.23-09-03916.2003

Fig. 1.

Fig. 1.

The effects of anandamide on bicuculline- and kainate-induced seizures in FAAH (+/+) and (−/−) mice. Treatment with anandamide (6.25–50 mg/kg, i.p.) 1 hr before administration of either bicuculline (A; 4 mg/kg, i.p.) or kainate (C; 15 mg/kg, i.p.) significantly enhanced the severity of seizures in FAAH (−/−) mice (filled bars) but not in FAAH (+/+) mice (open bars); n = 4 mice per group for 6.25 and 12.5 mg/kg anandamide, and n = 6–14 mice per group for 25 and 50 mg/kg anandamide. Pretreatment with a low dose of anandamide (6.25 mg/kg, i.p.) did not affect the seizure responses to high doses of bicuculline (B; 6 mg/kg) or kainate (D; 25 mg/kg) in FAAH (+/+) or (−/−) mice;n = 6–14 mice per group. For A–D, seizure scores are presented as mean ± SEM. All data were compared with the Mann–Whitney U test. ★p < 0.05 for FAAH (+/+) versus FAAH (−/−) mice receiving the same treatment. *p < 0.05 and ***p < 0.001 for FAAH (−/−) mice under different treatment conditions.