Fig. 4.

Seizure sensitivities of naive FAAH (+/+) and (−/−) mice. In response to high (30 mg/kg, i.p.), but not low (15 and 25 mg/kg), doses of kainate, FAAH (−/−) mice exhibited more intense seizures (A, filled bars) and reduced survival (B, solid line) compared with FAAH (+/+) mice (A, open bars; B, dashed line). No genotype differences were observed in the severity of seizures induced by low (4 mg/kg, i.p.) and high (6 mg/kg, i.p.) doses of bicuculline (C). **p < 0.01 for FAAH (+/+) versus (−/−) mice receiving the same treatment (Mann–Whitney U test). The survival curve (B) showed a significantly higher mortality for FAAH (−/−) mice than for FAAH (+/+) mice (p < 0.01; Fisher's exact test) after treatment with 30 mg/kg kainate. n = 10 mice per group.