Table 1.

Endogenous levels of NAEs in brain regions of FAAH (+/+) and (−/−) mice

Brain regions	NAE levels (pmol/gm wet weight), mean ± SEM
	Anandamide		OEA		PEA
	+/+	−/−	+/+	−/−	+/+	−/−
Hippocampus	3.3  ± 0.8	38.0  ± 2.8*	61.5  ± 13.6	1341.8  ± 123.0	154.5  ± 41.7	2149.50  ± 226.7
Cortex	1.8  ± 0.1	26.0  ± 2.4	55.4  ± 7.2	1094.7  ± 130.7	103.3  ± 27.6	1685.33  ± 59.3
Cerebellum	1.3  ± 0.3	29.7  ± 2.1	101.0  ± 20.1	1669.8  ± 161.8	237.2  ± 56.0	2401.67  ± 164.9

Levels for anandamide, OEA, and PEA were significantly higher in all three brain regions in FAAH (−/−) mice compared with FAAH (+/+) mice (p < 0.001; unpaired t test;n = 3–6 per group). Anandamide levels in FAAH (−/−) hippocampus were higher than in FAAH (−/−) cortex and cerebellum (

^*p < 0.05; unpaired ttest).