Fig. 8.
Clonazepam reduces the number of bursts, but not burst morphology, in multiunit activity recorded from TRN. Top, Multiunit recording from TRN in an α1(H101R) mouse in control conditions and after the application of 100 nm CZP (calibration: 1 sec). a and b show a population burst in each of the two conditions on an expanded time scale (calibration: 25 msec). Note the spikes of varying amplitudes and high interspike frequency, suggesting that the population burst contains spikes from multiple bursting RE cells. The top traces together with a and b show that fewer RE cell bursts occur in CZP than in control conditions. cand d show a burst, likely from a single RE cell, in the two conditions (calibration: 10 msec). In this experiment, one to three bursts that had similar spike morphologies and overall burst pattern were discernable in each control sweep compared with at most one burst from this presumed unit that was visible in each CZP sweep (data not shown). In both conditions, these bursts contained four to five spikes, consistent with the idea that although CZP may decrease the number of RE cell bursts, the number of spikes in each burst by this RE cell does not change dramatically.