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. 2019 Sep 12;14(9):e0221899. doi: 10.1371/journal.pone.0221899

Fig 5. Dose response of airways to Methacholine shows a decreased contractility in GSTCD-/- mouse lungs following LPS treatment.

Fig 5

Dose-response curves were produced (A) GSTCD+/+ (B) GSTCD-/- by applying different doses of Mch (0.001 to 100 μM) to the slices for five minutes. Percentage contraction of airways during the last minute from 2 or 3 slices each animal was averaged and a total of 6 animals in each group were compared. In the GSTCD-/- group dose-response curves were right-shifted. *P <0.05 compared with the same concentration following LPS treatment.