Table 3. Stem MAb neutralization against A/Puerto Rico/8/1934 escape mutants.
HA-pseudovirus neutralization titer (μg/ml) | Plaque reduction titer (μg/ml) | ||||||
---|---|---|---|---|---|---|---|
Mutants | 4C2 (IgG1) | C179 | CR6261 | FI6 | 4C2 (IgG1) | C179 | FI6 |
WT | 0.6 | 0.31 | 0.09 | 0.11 | 12.8 | 27.7 | 3.7 |
K55E | 3.42 | 2.02 | 0.43 | 0.53 | 35.2 | 25.7 | 2.4 |
V444L | 3.01 | 1.73 | 0.38 | 0.49 | 29.2 | 68.8 | 7.1 |
K55E.V444L | 4.53 | 2.81 | 0.42 | 0.54 | 63.2 | 91.2 | 5.9 |