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. 2019 Sep 12;17(9):e3000418. doi: 10.1371/journal.pbio.3000418

Fig 5. Loss of Lats1/2 induces M2 macrophage polarization.

Fig 5

P and PL mice were treated with 180 mg/kg/d of TAM for 5 consecutive days; cells were isolated from both groups 4 days later (n = 3). (A) F4/80 IHC staining in P and PL mice on Day 4 after TAM injection. (B) M2 macrophage-specific genes Ym-1, Ccl17, Tgf-β and IL10 were elevated in sorted macrophages of PL mice. (C) M1 macrophage-specific genes Tnf-α, Socs1, and Nos2 were not significantly changed. **P < 0.01, *P < 0.05. Underlying numerical values can be found in S1 Data. IHC, immunohistochemistry; LATS1, large tumor suppressor 1; P, control; PL, double knockout; TAM, tamoxifen.