Fig. 1.

Schematic of ganglion cell simulation. The simulation describes the transformation between the input current and membrane voltage of a cell. The cell was simulated as a single compartment with leak, capacitive, cellular noise, and Na⁺ currents (see Eq. 13). If an Na⁺ spike was generated, the simulation was switched to voltage clamp and forced to repolarize along the voltage trajectory of an experimentally measured action potential. The Na⁺ current parameters were updated continuously during this voltage trajectory. After the voltage returned to rest, the simulation was switched back into current clamp, and the voltage was controlled again by the currents.