Fig. 8.

Comparison of variance adaptation in real and simulated ganglion cells. Several minutes of Gaussian current fluctuations (bandwidth, 0–50 Hz) of 16 and 144 pA²variance were injected into experimental and simulated cells. Adaptation in the computer simulated spike train was analyzed using the static nonlinear model and treated identically to that of an experimental cell. A, Adaptation in an experimental cell. Left, Linear filters. Right, Filters with the time axes normalized to the time-to-peak of each filter. B, Simulation lacking slow Na⁺ inactivation. C, Simulation with slow Na⁺ inactivation. Insets show that the static nonlinearities overlapped in all cases. Simulation parameters are given in Table 1 and Equations 6-12.