Fig. 3.

Spatial arrangement of OCAM⁺and OCAM⁻ glomeruli in the wild-type and Sema3A-deficient OBs. In adult wild-type OB (A, C, +/+), OCAM⁻ (open circles) and OCAM⁺ (filled circles) glomeruli showed a segregated distribution. OCAM⁺glomeruli occurred in the tongue-like area (A,open arrow) of the anteromedial region and in the posteroventral zones (zones II–IV) of the OB. In littermate Sema3A-deficient mice (B, D, −/−), OCAM⁺ glomeruli in the tongue-like area disappeared from the anteromedial region, and the OCAM⁺ and OCAM⁻ boundary became indistinct. C, D, In the left OB of a wild-type mouse (C) and that of a littermate Sema3A-deficient mouse (D), P2 glomeruli (P2,open arrows) were located at approximately similar positions; two P2 glomeruli were at the ventrolateral region, and one P2 glomeruli was at the ventromedial region. All of the P2 glomeruli were OCAM⁺. A, Anterior;P, posterior; D, dorsal;LV, lateroventral; MV, medioventral.