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. 2003 Feb 15;23(4):1390–1397. doi: 10.1523/JNEUROSCI.23-04-01390.2003

Fig. 5.

Fig. 5.

Optical imaging of intrinsic signals in response to odorant stimulation recorded from the dorsal surface of the OB of adult wild-type and Sema3A-deficient mice. A, B, Spatial distribution of the response to valeric acid (5COOH) stimulation recorded from the right and left OBs in an adult wild-type mouse (A, +/+) and a Sema3A-deficient mouse (B, −/−). C–J, Spatial distribution of the optically recorded intrinsic signals in response to a homologous series of fatty acids and aliphatic alcohols. The areas of the activated glomeruli are enclosed by the colored circles. C and D show the fatty acid- (red), phenol- (green), and aliphatic alcohol- (blue) responsive domains in two different adult wild-type mice, whereas E–J show these domains in six different Sema3A-deficient mice. In the wild-type mice, the fatty acid-responsive domains were consistently observed at the anterocentral part of the dorsal OB. Fatty acids also activated a cluster of glomeruli at the posteromedial part (C, D,arrows). Aliphatic alcohols and phenol invariably activated glomeruli in the lateral domain. The Sema3A-deficient OB showed an alteration in the spatial arrangement of the fatty acid-, aliphatic alcohol-, and phenol-responsive domains. Dashed lines represent the midline separating the left and right OBs. Scale bar, 500 μm. 3COOH, Propionic acid;7COOH, heptylic acid; 4OH, butyl alcohol;6OH, hexyl alcohol; 8OH, octyl alcohol;A, anterior; L, lateral;P, posterior; M, medial.