Fig. 6.

A small fraction of infected glial cells is sufficient to protect neurons from oxidative glutamate toxicity.A, Representative images from glial–neuron coculture setup (see Fig. 1A). Within a typical coculture infected glia (green) and uninfected neurons (red) can be observed. Uninf, Uninfected glia transplanted. B, Group data obtained from plate scanning for NSE (red) fluorescence.C, Decreased neuronal viability is demonstrated by a loss of red fluorescence. The addition of Nrf2-overexpressing glia restores NSE expression to levels found in an ad-GFP-infected group that was not exposed to glutamate. Data represent the mean ± SEM from three separate experiments performed in quadruplicate; *p < 0.05. Scale bar, 80 μm.