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. 2003 Apr 15;23(8):3394–3406. doi: 10.1523/JNEUROSCI.23-08-03394.2003

Table 1.

Evaluation of Na+-independentl-[3H]-glutamate uptake by systemx c− in ad-Nrf2-infected mixed immature cortical cultures: percentage increase and pharmacology of induced uptake

ad-GFP ad-Nrf2 ad-Nrf2DN
100% 372  ± 82%* 76.7  ± 7.1%*
Compound ad-GFP (%) ad-Nrf2 (%)
None 100  372  ± 82
l-Cystine 115.4  ± 13.2 86.5  ± 16.01-159
Quisqualic acid 77.8  ± 10.8 71.8  ± 10.51-159
Homocysteic acid 74.2  ± 22.0 80.0  ± 31.01-159

Data represent the mean ± SEM of five independent experiments performed in quadruplicate.

*

p < 0.05, compared with ad-GFP control.

F1-159: p < 0.05, compared with ad-Nrf2 control with no compounds. Uptake assay performed on mixed neuron/glial immature cultures. The basal rate ofl-[3H]-glutamate uptake by ad-GFP-expressing cultures is 59.1 ± 5.7 fmol/mg protein per min.