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GABAAR activation inhibits proliferation of PSA-NCAM+ progenitors by blocking MAPK signaling pathways. Histogram shows that the increase of [3H]-thymidine incorporation induced by the GABAAR antagonist SR95531 (10 μm) and by EGF (20 ng/ml) was significantly blocked by U0126 (10 μm), a specific inhibitor of the mitogen-activated protein kinase kinases MEK1 and MEK2 (n = 5; Student's t test; *p < 0.05, **p < 0.01).
