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. 2003 Apr 15;23(8):3491–3497. doi: 10.1523/JNEUROSCI.23-08-03491.2003

Fig. 6.

Fig. 6.

Effects of local injection of CRF antagonist on LC response to CeN stimulation. A, PSTHs and rasters constructed around CeN stimulation (Ce stim) (500 μA trains; horizontal bar) for an LC unit showing a monophasic response (top). This response is completely blocked by the CRF antagonist (bottom; nonparametric Newman–Keuls analog test; p < 0.05). B, Same representation for another single unit showing a biphasic response to CeN stimulation. Before αhCRF injection (top), the cell exhibits a biphasic response with an early (shaded area) and a late phase. After the injection (bottom), the early response is greatly attenuated (30% of its preinjection value; nonparametric Newman–Keuls analog test; p < 0.05), whereas the late phase is spared.