Table 1.
Nicotinic AChR currents from wild-type rodent VTA DA, VTA non-DA, and SNc DA neurons1-a
| Current | Rat | Mouse | |||||
|---|---|---|---|---|---|---|---|
| VTA DA | VTA non-DA | SNc DA | Current | VTA DA | VTA non-DA | SNc DA | |
| Fast | 90 ± 20 pA | 130 ± 40 pA | 50 pA | Fast | 70 ± 20 pA | 90 ± 40 pA | 40 ± 10 pA |
| (10/33) | (9/29) | (1/23) | (11/47) | (8/31) | (3/37) | ||
| Slow | 110 ± 20 pA | 120 ± 30 pA | 130 ± 5 pA | Slow | 83 ± 7 pA | 77 ± 8 pA | 78 ± 9 pA |
| (33/33) | (22/29) | (22/23) | (42/47) | (27/31) | (31/37) | ||
| None | (0/33) | (7/29) | (1/23) | None | (4/47) | (3/31) | (6/37) |
F1-a
Currents are given as mean ± SEM. Numbers in parentheses indicate the number of responding neurons/total number of neurons investigated. Note the lower incidence of the fast nAChR-mediated current in SNc DA neurons, compared with VTA neurons, in contrast to the similar incidence of the slow current in all neuronal subsets studied.