Table 3. Summary of bioassays with Tg(SHaPrP) mice that were inoculated with plasma coated PSR1 beads.
| Plasma Pools | Attack rate (Clinical TSE/total inoculated) |
Mean incubation period (days) | Estimated titers* Log LD50 units ml-1 [42, 47] |
|---|---|---|---|
| pre-symptomatic hamster, 20 animals, 30 dpi | 0% (0/8) | 8 survivor terminated at 322 dpi | |
| pre-symptomatic hamster, 20 animals, 50 dpi | 50% (2/4) | 56 and 85 dpi (71 ± 21 dpi) (plus 2 survivor terminated at 211 dpi) |
3.2 ± 2.2 |
| symptomatic hamster, 14 animals, 104–106 dpi | 100% (8/8) | 74 ± 3 dpi | 2.8 ± 0.3 |
| symptomatic hamster, 15 animals, 117–118 dpi | 100% (4/4) | 76 ± 5 dpi | 2.4 ± 0.5 |
| symptomatic hamster, 11 animals, 143 dpi and 154 dpi | 81% (13/16) | 94 ± 5 dpi (plus 3 survivor terminated at 211 dpi) |
1.9 ± 0.5 |
| non-infected hamster, 2 animals, 80 days after PBS inoculation | 0% (0/2) | 8 survivor terminated at 308 dpi |