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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2019 Jul 17;1862(9):194402. doi: 10.1016/j.bbagrm.2019.07.003

Figure 3: The m6A writer complex.

Figure 3:

The m6A writer complex targets RNAs as they are transcribed. The m6A-METTL complex (MAC; shown in pink), consisting of the METTL3/14 heterodimer, is the catalytically active subcomplex which methylates adenosine at sites matching the RRACH consensus. WTAP is the major scaffolding protein that connects the MAC and m6A-METTL-associated complex (MACOM). The composition and/or activity of MACOM subunits can influence the distribution of m6A across a transcript. VIRMA and HAKAI favor 3’ methylation, while RBM15/15B facilitates 5’ methylation.