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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2019 Jul 17;1862(9):194402. doi: 10.1016/j.bbagrm.2019.07.003

Figure 4: Factors influencing the distribution of m6A and m6Am on mammalian mRNAs.

Figure 4:

The overall m6A landscape in physiological conditions is determined primarily by the distribution of consensus motifs recognized by the methyltransferases (CAPAM, METTL3/14). However, it can be influenced by demethylases such as FTO, which prunes m6A from introns and across the transcript. Moreover, certain components of the MACOM, namely RBM15/15B and VIRMA, can favor methylation at the 5’ and 3’ ends respectively. Finally, there is evidence that histone modifications can influence m6A deposition.

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