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. Author manuscript; available in PMC: 2020 Sep 1.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2019 Jul 17;1862(9):194402. doi: 10.1016/j.bbagrm.2019.07.003

Figure 6: m6A methylation influences key events during development and differentiation.

Figure 6:

A: A: In bone marrow stem cells (BMSC), translation of the parathyroid hormone receptor (PTH1R) mRNA is regulated by METTL3-mediated methylation to favor production of osteoblasts. B: B: m6A influences hematopoiesis at multiple steps. C: Following nerve injury, regeneration associated genes are subject to m6A-mediated regulation to promote recovery. D: Neural Progenitor Stem Cells (NPSCs) rely on m6A methylation for self-renewal and for a sharp transition upon receipt of a cue to differentiate. See text for more details.