Box Figure: Alternative methyltransferases recognize distinct properties of their target RNAs.
A: METTL16 targets a unique structure found in U6 snRNA, MALAT lncRNA, and the 3’ UTR of the MAT2A mRNA as well as other RNAs. B: CAPAM targets the 2’O-methyladenozyne found adjacent to the 5’ cap in many RNA polymerase II transcripts. C: DIMT1L targets two adjacent adenosine residues in a stem-loop structure of 18S rRNA.