Table 2.

Groningen Radiation-Induced Xerostomia Questionnaire Baseline and AUC Scores for Patients Receiving Placebo vs NAC

	Scoresa
				Total AUC During RT
	Baseline (Cycle 0)			(All Cycles)			Post RT at 3 mo
Characteristics	Placebo	NAC	P Valueb	Placebo	NAC	P Valueb,c	Placebo	NAC	P Valueb
Sticky saliva
Daytime	11.1	6.5	.38	45.2	26.1	.04	50.0	35.2	.40
Nighttime	8.9	5.6	.87	34.5	29.1	.56	55.6	22.2	.24
Total	10.2	6.1	.55	40.9	27.2	.12	51.9	30.9	.29
Xerostomia
Daytime	15.9	13.9	.58	44.1	27.3	.02	46.3	29.6	.59
Nighttime	29.6	20.4	.44	39.8	31.3	.22	36.1	27.8	.76
Total	20.5	16.0	.40	43.8	28.5	.02	42.2	28.9	.65

Abbreviations: AUC = area under the curve; NAC = N-acetylcysteine; RT = radiotherapy.

^aLower scores indicate better quality of life.

^bCalculated with equal variance t testing.

^cBold indicates statistical significance.