Table 3. TEG combination parameters ratio CKH.R/CK.R, ratio CK.R/CKH.R, and ΔCK.R − CKH.R versus anti-Xa for UFH and LMWH.
| Heparin | Combination parameter | Cutoff | Subtherapeutic vs. anti-Xa | Therapeutic vs. anti-Xa | Supratherapeutic vs. anti-Xa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Accuracy (%) | Low | High | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Sensitivity (%) | Specificity (%) |
PPV (%) | NPV (%) | ||
| UFH | Ratio CKH.R/CK.R | 91 | 0.34 | 0.20 | 92 | 95 | 92 | 95 | 72 | 98 | 89 | 93 | 98 | 92 | 90 | 99 |
| Ratio CK.R/CKH.R | 90 | 3.67 | 5.27 | 93 | 92 | 88 | 96 | 67 | 98 | 88 | 92 | 98 | 94 | 92 | 99 | |
| ΔCK.R − CKH.R | 92 | 19 | 33 | 94 | 94 | 91 | 96 | 78 | 97 | 88 | 95 | 97 | 97 | 96 | 98 | |
| LMWH | Ratio CKH.R/CK.R | 80 | 0.70 | 0.43 | 88 | 95 | 86 | 96 | 68 | 86 | 71 | 85 | 85 | 88 | 85 | 89 |
| Ratio CK.R/CKH.R | 78 | 1.45 | 2.59 | 93 | 90 | 76 | 97 | 65 | 85 | 68 | 84 | 80 | 92 | 89 | 86 | |
| ΔCK.R − CKH.R | 79 | 3.45 | 12.99 | 91 | 92 | 78 | 97 | 65 | 85 | 68 | 84 | 82 | 91 | 87 | 87 | |
Abbreviations: CK, kaolin; CKH, kaolin with heparinase; LMWH, low-molecular-weight heparin; NPV, negative predictive value; PPV, positive predictive value; R, reaction time; UFH, unfractionated heparin.