Table 1.

Phases of WHIMS

Study Phase	WHIMS (including extension)	WHIMS-ECHO	SCAP
Years in Effect	1996-2007	2007-present
Assessments
Cognitive	• Annual face-to-face administered 3MSE (25); cutpoint triggered cases that received additional assessments • CERAD neuropsychological battery (35)	• Annual telephone-administered cognitive battery (7); TICSm (26) triggered cases that also collected Dementia Questionnaire from proxy
Clinical	• CERAD clinical evaluation (35) • Prime MD psychiatric interview (36) • Geriatric Depression Scale-Short Form (37)	• Geriatric Depression Scale-Short Form (37) • WHI Insomnia Rating Scale (38)
Proxy	CERAD cognitive and behavioral changes assessment (35)	Dementia Questionnaire (17) administered to knowledgeable proxy	Dementia Questionnaire (17) administered to knowledgeable proxy
Adjudication	Central Adjudication Committee using all prior data; applying standardized diagnostic criteria (28, 29)	Central Adjudication Committee using all prior data; applying standardized diagnostic criteria (28, 29)	Central Adjudication Committee using all prior data; applying standardized diagnostic criteria (28, 29)
Cases identified	Probable dementia: Mild Cognitive Impairment:	Probable dementia: Mild Cognitive Impairment:	Probable dementia: Mild Cognitive Impairment:

Notes: CERAD=Consortium to Establish a Registry for Alzheimer’s Disease; TICSm=Telephone Interview for Cognitive Status-modified; 3MSE=Modified Mini Mental State Exam; WHI=Women’s Health Initiative; WHIMS=Women’s Health Initiative Memory Study; ECHO=Epidemiology of Cognitive Health Outcomes; SCAP=Supplemental Case Ascertainment Protocol