Table 2.
Comparison of Variables of Interest for Two Different Adjudication Ascertainment Protocols
| N (%) | |||
|---|---|---|---|
| Variable | WHIMS-Main (n=6219) | WHIMS-SCAP (n=1260) | P-Value |
| Age at start of study | <.0001 | ||
| 64-69 | 2972 (47.8%) | 475 (37.7%) | |
| 70-74 | 2187 (35.2%) | 489 (38.8%) | |
| 75+ | 1060 (17.0%) | 296 (23.5%) | |
| Race/Ethnicity | 0.0002 | ||
| Black/African American | 449 (7.24%) | 86 (6.84%) | |
| Hispanic/Latino | 164 (2.64%) | 15 (1.19%) | |
| Other | 231 (3.72%) | 25 (1.99%) | |
| White | 5361 (86.4%) | 1132 (90.0%) | |
| Education | 0.5249 | ||
| < High school | 486 (7.84%) | 89 (7.09%) | |
| High school/GED | 1384 (22.3%) | 264 (21.0%) | |
| Some college | 2481 (40.0%) | 521 (41.5%) | |
| College + | 1851 (29.8%) | 382 (30.4%) | |
| APOE e4 positive | <.0001 | ||
| No | 3556 (57.2%) | 827 (65.6%) | |
| Yes | 1227 (19.7%) | 253 (20.1%) | |
| Missing | 1436 (23.1%) | 180 (14.3%) | |
| Treatment Assignment | 0.1523 | ||
| HT | 3094 (49.8%) | 599 (47.5%) | |
| Placebo | 3125 (50.2%) | 661 (52.5%) | |
| Prior HT | 0.2262 | ||
| No | 4259 (68.5%) | 885 (70.2%) | |
| Yes | 1958 (31.5%) | 375 (29.8%) | |
| BMI | 0.5079 | ||
| < 25 | 1805 (29.2%) | 361 (28.8%) | |
| 25-29 | 2258 (36.5%) | 446 (35.5%) | |
| 30-34 | 1358 (22.0%) | 275 (21.9%) | |
| 35+ | 757 (12.3%) | 173 (13.8%) | |
| Hypertension | <.0001 | ||
| None | 3235 (52.0%) | 514 (40.8%) | |
| Current/controlled | 967 (15.6%) | 229 (18.2%) | |
| Current/uncontrolled | 2015 (32.4%) | 517 (41.0%) | |
| Prior CVD | <.0001 | ||
| No | 5594 (90.0%) | 1079 (85.6%) | |
| Yes | 623 (10.0%) | 181 (14.4%) | |
| Diabetes | <.0001 | ||
| No | 5744 (92.5%) | 1098 (87.2%) | |
| Yes | 465 (7.49%) | 161 (12.8%) | |
| Smoking | <.0001 | ||
| Never Smoked | 3377 (55.1%) | 530 (42.8%) | |
| Past Smoker | 2383 (38.9%) | 547 (44.2%) | |
| Current Smoker | 368 (6.01%) | 161 (13.0%) | |
| Baseline 3MS | 0.5187 | ||
| < 90 | 636 (10.3%) | 115 (9.27%) | |
| 90-94 | 1415 (23.0%) | 292 (23.5%) | |
| 95-100 | 4111 (66.7%) | 834 (67.2%) | |
Abbreviations: WHIMS=Women’s Health Initiative Memory Study; SCAP=Supplemental Case Ascertainment Protocol; HT=hormone therapy; BMI=body mass index; CVD=cardiovascular disease; 3MS= Modified Mini Mental State Exam.