Skip to main content
. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Cell Host Microbe. 2019 Aug 22;26(3):359–368.e8. doi: 10.1016/j.chom.2019.08.002

Figure 5. Structural analysis of the SIVsmm Nef tetherin binding pocket.

Figure 5.

(A) Sequence alignment of Nef dileucine loops between SIVsmm Nef and other Nef species. Key residues in SIVsmm Nef for tetherin and AP-2 binding are highlighted. (B) Ribbon representation of SIVsmm Nef mutations investigated with SMM tetherin GDIW motif shown for reference. (C) FP assay indicates that Nef mutations in multi interfaces impair tetherin binding. See also Figure S5