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(A) A structural model highlighting the two major cargo binding sites targeted by Nef, the dileucine binding site (ExxxLL) and the tyrosine binding site (YxxΦ), and the host factors downregulated by interactions at these sites. (B) A structural model highlighting the Nef mutations that had effects on Nef-dependent downregulation of host tetherin, SERINC5 and immune receptors.
