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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Eur J Neurosci. 2019 May 2;50(4):2663–2682. doi: 10.1111/ejn.14418

Fig. 1.

Fig. 1

The flow diagram shows the overall experimental design and timeline for the experiment (a) (see methods for details). An Infusion Criterion (IC) procedure was used for the acquisition of cocaine self-administration (b). Both IntA rats and LgA rats escalated their intake/session to a similar extent across all 30 self-administration sessions (c,d). LgA rats consumed far more cocaine on average than IntA rats over the course of 30 self-administration sessions (e). (Th: Threshold Test, IntA: Intermittent Access, LgA: Long Access, IV/MD surgery: Intravenous catheter/Microdialysis guide cannula surgery). In panels c and d each point represents the average of three consecutive self-administration sessions. See methods for the number of rats included in each group and panel. Values represent means ± SEMs, * represents a significant difference (p<0.05) between IntA and LgA groups.