Table 1.

Other analytes of interest following a cocaine infusion. Microdialysis allows for the analysis of a number of analytes in addition to DA. Select neurochemicals of interest are shown here. A self-administered cocaine infusion increased extracellular levels of Glutamate and 3-MT (a dopamine metabolite) in all rats. Cocaine-evoked 3-MT was greater in IntA rats than LimA rats or LgA rats.

Analytes	Group Differences	Peak cocaine-induced change from baseline	Std. Error
Glutamate	No	+32%*	+/− 10.3%
GABA	No	+1.4%	+/−4.6%
ACh	No	−10%	+/−33%
3-MT	Yes	IntA: +98%* Lim&LgA: +25%*	+/−26% +/−9.1%
DOPAC	No	−9.9%	+/− 4.1%
HVA	No	+0.5%	+/−5.2%

^*indicates a significant (p<0.05) change in analyte concentration following the cocaine infusion relative to baseline.