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. Author manuscript; available in PMC: 2020 Sep 12.
Published in final edited form as: J Med Chem. 2019 Apr 18;62(17):7618–7642. doi: 10.1021/acs.jmedchem.9b00370

Figure 9.

Figure 9

Antibacterial profiles of select FSM analogues identified from microbiological studies. Several analogues demonstrate high antibacterial potencies and overcome specific macrolide resistance mechanisms. Resistant strain details are the following: iErmA, inducible erythromycin ribosome methyltransferase A; MsrA, macrolide streptogramin resistance efflux pump A; ErmB, erythromycin ribosome methyltransferase B; MefA, macrolide efflux protein A.