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Discrimination of the aggregate model with neuropathological lesions in participants younger than 80 years (gray line with triangle marker) and 80 years and older (black line with circle marker) using the area under the Receiving Operator Curve (ROC). The aggregate model includes neurofibrillary tangles, neuritic plaques, Lewy body disease, infarcts, hyaline arteriolosclerosis, cerebral amyloid angiopathy, siderocalcinosis, hippocampal sclerosis and argyrophilic grain disease.
