Table 3.
Odds ratio of cognitive impairment according to the presence of neuropathological lesions, stratified by age groups (n = 1089).
| Age <80 yo (n = 677) | Age ≥80 yo (n = 412) | P‐value for interaction | |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | with age group† | |
| BB NFT score | 0.27 | ||
| 0–II | 1 (reference) | 1 (reference) | |
| III–IV | 2.79 (1.56–4.97) | 1.50 (0.86–2.63) | |
| V–VI | 18.19 (6.04–54.80) | 4.94 (2.07–11.82) | |
| CERAD score | 0.37 | ||
| None/Scarce | 1 (reference) | 1 (reference) | |
| Moderate | 0.81 (0.43–1.52) | 1.41 (0.76–2.61) | |
| Frequent | 0.74 (0.36–1.52) | 1.10 (0.58–2.09) | |
| Infarcts | 6.92 (3.75–12.76) | 3.26 (1.66–6.41) | 0.04 |
| Hyaline arteriolosclerosis | 2.36 (1.29–4.30) | 1.86 (1.05–3.29) | 0.23 |
| CAA | 0.89 (0.31–2.55) | 2.29 (0.75–6.92) | 0.23 |
| Hippocampal sclerosis | 4.49 (0.78–25.95) | 1.72 (0.57–5.20) | 0.35 |
| Siderocalcinosis | 1.81 (1.10–2.99) | 1.23 (0.70–2.14) | 0.26 |
| BB LBD score | 0.11 | ||
| 0 | 1 (reference) | 1 (reference) | |
| I–III | 1.58 (0.57–4.39) | 0.57 (0.23–1.41) | |
| IV–VI | 1.97 (0.78–4.99) | 3.50 (1.46–8.39) | |
| AGD | 0.56 (0.30–1.04) | 0.73 (0.42–1.25) | 0.25 |
| TDP‐43‡ | 0.95 (0.25–3.63) | 7.76 (1.83–32.9) | 0.04 |
Logistic regression, adjusted for sex, race, education and other neuropathological lesions presented in the table.
†
P‐value for the interaction term between each neuropathological lesion and the age group.
‡
Information available for 410 participants.
Abbreviations: BB = Braak & Braak; NFT = neurofibrillary tangles; CERAD = Consortium to Establish a Registry for Alzheimer’s Disease; CAA = cerebral amyloid angiopathy; LBD = Lewy Body Disease; AGD = argyrophilic grain disease; TDP‐43 = transactive response DNA‐binding protein 43 kDA.