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. 2019 Sep 12;9:225. doi: 10.1038/s41398-019-0559-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a The fractional anisotropy (FA) was increased in the corpus callosum (CC) (0.547 ± 0.008 vs. 0.478 ± 0.01, n = 9 per strain, p = 3.7E-05) and decreased in the dorsomedial striatum (DMS) (0.18 ± 0.01 vs. 0.20 ± 0.01, n = 9 per strain, p = 0.01) and superior cerebellar peduncle (SCP) (0.28 ± 0.02 vs. 0.36 ± 0.01, n = 9 per strain, p = 0.003) of TH mice. No differences were observed in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and nucleus accumbens (NAcc). b The same three brain regions showed a decrease in the mean diffusivity (MD) in TH mice: CC (7.44E-04 ± 5.56E-06 vs. 7.78E-04 ± 1.21E-05, n = 9 per strain, p = 0.03), DMS (7.17E-04 ± 1.10E-05 vs. 7.58E-04 ± 1.18E-05, n = 9 per strain, p = 0.02) and SCP (6.50E-04 ± 2.89E-05 vs. 7.44E-04 ± 1.30E-05, n = 9 per strain, p = 0.01). c, d Compulsivity-like behavior as shown by the spontaneous alternation is positively correlated to the FA in DMS and SCP (r = 0.734, n = 18, p = 0.002 and r = 0.548, n = 18, p = 0.02, respectively)