Fig. 8.

RGLS4326 does not cause hematopoietic or kidney toxicity in monkeys. Male cynomolgus monkeys (n = 3/group) were dosed SC QW with 0, 3, 30, or 100 mg kg⁻¹ of RGLS4326 for 7 consecutive weeks (QWx7). Prior to the study, animals were acclimated to the study room for 14 days. On the final day of acclimation, animals weighed between 2.8 and 6.1 kg and were 3 to 6 years of age. Blood was collected for hematology and serum chemistry analysis before and at 48 h after the last dose. Specimens were analyzed using an Advia 120 automated hematology analyzer and an AU680 chemistry analyzer. Comparison between pre-dose and post-QWx7 values for each treatment groups indicated no hematological abnormalities (a–d) and no renal toxicity (e–h) following RGLS4326 treatment. Error bars represent standard deviations. Source data for Fig. 8a–h is provided in Source data files