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. 2019 Sep 12;9:13187. doi: 10.1038/s41598-019-49784-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Effect of compound 9b on the acetylation status of Histone H3 and α-tubulin. SH-SY5Y cells were incubated with the indicated concentrations of 9b for 24 h and the acetylation status of Histone H3 and α-tubulin was measured by western blot. DMSO (D) and SAHA (1 μM) were employed as a negative and a positive control, respectively. (B) Densitometry analysis of Ac-Histone H3 and (C) Ac-α-tubulin. Fold increase of Ac-Histone H3 and Ac-α-tubulin were analyzed using Image J software. Control value = 1. Data are presented as the mean ± SD (n = 3).