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Effective permeability (Pe) of compound 9b and SAHA in the PAMPA-BBB assay.
| Compounds | Pe (10−6 cm/s)a | CNS +/− classificationb |
|---|---|---|
| Progesterone | 35.52 ± 0.33 | CNS + |
| Lidocaine | 18.98 ± 3.05 | CNS + |
| Theophylline | 0.10 ± 0.02 | CNS − |
| 9b | 27.15 ± 1.59 | CNS + |
| SAHA | 2.77 ± 0.05 | CNS − |
aData are expressed as the mean ± SD from three independent experiments. bCNS + indicates (Pe > 10) and CNS - indicates (Pe < 10).
