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HDAC inhibition activity of compound 9b and SAHAa.
| Class | Enzymes | 9b (IC50; nM) | SAHA (IC50; nM) |
|---|---|---|---|
| I | HDAC1 | 84.9 ± 25.1 | 102.7 ± 5.9 |
| HDAC3 | 142.2 ± 45.7 | 61.1 ± 1.54 | |
| IIa | HDAC7 | 3,036 ± 788.5 | 29,290 ± 1,325 |
| IIb | HDAC6 | 95.9 ± 0.78 | 198.5 ± 103.0 |
aData are presented as the mean ± SD (n = 2).
