Fig. 5.

Assessment of GST activity. a, b GST activities toward 4-HNE were measured in the cytosol of inner ear tissues from male (a) and female (b) Gsta4^+/+ and Gsta4^−/− mice prior to and after cisplatin treatment. n = 3, *p < 0.05 vs. precisplatin (two-way ANOVA). Error bars represent ± s.e.m. c, d 4-HNE-positive SGNs were counted and quantified in the apical, middle, and basal regions of cochlear tissues from male (c) and female (d) Gsta4^+/+ and Gsta4^−/− mice after cisplatin treatment. The quantification shows a mean of at least three independent experiments (n = 3), *p < 0.05 vs. +/+ (two-way ANOVA). Error bars represent ± s.e.m. Source data are provided as a Source Data file