Fig. 9.

Assessment of oxidative DNA damage in the inner ears of Gsta4^+/+ and Gsta4^−/− mice. a Levels of 8-oxoguanine as an oxidative DNA damage marker were measured in the inner ear tissues from cisplatin-treated male and female Gsta4^+/+ and Gsta4^−/− mice. n = 5, ^*p < 0.05 vs. +/+ (unpaired two-tailed Student t test). Error bars represent ± s.e.m. b Levels of 8-oxoguanine were measured in the inner ears from cisplatin-treated male and female Gsta4^−/− mice. The quantification shows a mean of at least four independent experiments (n = 4). Error bars represent ± s.e.m. c Levels of 8-oxoguanine were measured in the inner ears from cisplatin-treated female and OVX Gsta4^−/− mice The quantification shows a mean of at least four independent experiments (n = 4). Error bars represent ± s.e.m. M: male, F: female, O: ovariectomized female. Source data are provided as a Source Data file