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. 2019 Sep 12;10(9):675. doi: 10.1038/s41419-019-1925-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The miR-155-5p and miR-200a-3p mRNA levels in HCT116 cells and DLD-1 cells overexpressing BFAL1. b The miR-155-5p and miR-200a-3p mRNA levels in HCT116 cells and DLD-1 cells with BFAL1 knockdown. c Luciferase reporter assays were performed in HCT116 cells and DLD-1 cells overexpressing BFAL1. Luciferase reporters expressing wild-type or mutant human RHEB 3ʹ UTR were used (mean ± SD of three independent experiments, ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001). d Luciferase reporter assays were performed in HCT116 cells and DLD-1 cells with BFAL1 knockdown. Luciferase reporters expressing wild-type or mutant human RHEB 3ʹ UTR were used (mean ± SD of three independent experiments, ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001). e Xenograft tumors in the nude mouse model under different treatments (n = 5). f Statistical analysis of tumor sizes (mean ± SD, n = 5, ANOVA, **P < 0.01). g Analysis of tumor weights in different groups (mean ± SD, n = 5, ANOVA, **P < 0.01)