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. 2019 Sep 12;10:4153. doi: 10.1038/s41467-019-12137-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — In vitro binding and neutralization. a The neutralization activity of RB1 against laboratory strains RSV A (Long) and b RSV B (Washington) with palivizumab as an assay control antibody. Assays were run in duplicate, showing error bars at mean with standard deviation (SD). An IC₅₀ was calculated using a log versus response variable slope 4 parameter fit curve and represents the concentration of antibody required for a 50% reduction in the RSV infectivity in a microneutralization assay. c The neutralization activity of RB1 against laboratory strains HMPV A and B with MPE8 control antibody. Assays were run in triplicate, showing error bars at mean with standard deviation (SD). An IC₅₀ was calculated using a log versus response variable slope 4 parameter fit curve and represents the concentration of antibody required for a 50% reduction in the HMPV infectivity in a microneutralization assay. d The enzyme-linked immunoassay (ELISA) binding curves of RB1 binding to the pre-F and post-F protein conformations. The assay was run in duplicate showing error bars at mean with SD. An EC₅₀ was calculated and represents the concentration of antibody required for a 50% reduction in binding. Source data provided as a source data file