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. 2019 Sep 12;10(9):676. doi: 10.1038/s41419-019-1931-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — SMCs in full-serum medium were transduced with scramble or TFEB shRNA lentiviral particles as described in “Methods”. The cells were treated with vehicle or trehalose (100 mM). a Immunoblot analysis show the effects of TFEB silencing on protein expression of LC3 and p62/SQSTM1 in SMCs with trehalose for 24 h (n = 6). b Cell number counting after 24-h trehalose (n = 6). c MMP activity of SMCs after 48-h trehalose by a fluorometric MMP activity assay kit. (n = 4). d Scratch assay of SMCs with trehalose for 24 h (n = 6). Scale bar = 100 μm *P < 0.05 vs Scr